Preliminary Programme Overview.

Please note this preliminary programme is correct as per July 2019 and is subject to change.

Click here to download the print version of the programme.

Day 1: Thursday

Day 2: Friday

Day 3: Saturday

Day 1: Thursday, 4 June

Day 1: Thursday, 4 June 2020

8:00     Welcome message                                                     Local organizing committee

8:10     Meeting goals & plans                                               Jinnah, Pisani, Teller


I.
INTRODUCTION TO DYSTONIA 

 

             Where we are now?

8:20     Definition and classification of dystonia: How well is the 2013 Consensus Plan working

8:45     Dystonia syndromes: Overlapping or distinct?

9:10     What is the relationship between dystonia, Parkinson disease, essential tremor, and ataxia?

9:35     Current treatment for dystonia: What are the successes? What can we do better?

 

10:00   Coffee Break

 

             Late breaking news

10:30   TBA (chosen from posters submitted)

10:35   TBA (chosen from posters submitted)

10:40   TBA (chosen from posters submitted)

10:45   TBA (chosen from posters submitted)

 

             Point and counterpoint: Dystonia and tremor

10:50   Dystonia plus tremor = a discrete entity known as dystonic tremor

11:00   Dystonia plus tremor = two separate but frequently overlapping disorders

11:10   Discussion

            Hot topics: The science of phenotyping

11:20   Pseudodystonia: Does it differ from “real” dystonia?

11:30   Paroxysmal dyskinesias: A subtype of dystonia or a different entity?

11:40   Discussion

 

            Chair’s summary & discussion with audience

11:50   Chair’s summary of the morning session

12:00   Open discussion of morning session

 

12:30   Lunch Break & Poster Session (provided for all delegates)

All posters viewable for entire meeting: 1st third to present today from 13:30-14:30


II. SPECIAL TOPICS IN DYSTONIA


Understanding mechanisms through the science of phenotyping

14:30   Task-specific dystonia: What do they tell us about the etiology of dystonia?

14:50   Sex differences across the dystonias: How can we begin to delineate mechanisms?

15:10   Autoimmune mechanisms in dystonia: What can they tell us about the etiology of dystonia?

15:30   Dystonia in pediatrics: What can we learn from inherited metabolic disorders?

 

15:50   Coffee Break

 

             Point-counterpoint: Functional (psychogenic) dystonia.

16:20   Functional dystonia: The biological basis of a neurological disorder

16:30   Functional dystonia: A pseudodystonia of psychiatric origin

16:40   Discussion

 

            Point-counterpoint: Non-motor features of dystonia

16:50   Non-motor features of dystonia: Shared biological substrates for motor and non-motor feature

17:00   Non-motor features of dystonia: An expected side effect of a chronic disorder

17:10   Discussion

 

            Chair’s summary & discussion with audience

17:20   Chair’s summary of the afternoon session

17:30   Open discussion of afternoon session

 

19:00   WELCOME RECEPTION

Day 2: Friday, 5 June 2020

Day 2: Friday, 5 June 2020


III. ANATOMICAL BASIS FOR DYSTONIA

 

             What areas of the nervous system are responsible for dystonia?

8:00     Current concepts on integration of normal movement: cortex, basal ganglia and cerebellum

8:20     Structural imaging of human dystonia: Insights into cause or modern phrenology?

8:40     Functional imaging of human dystonia: Some common themes or too much heterogeneity?

9:00     Anatomical basis for dystonia: What can we learn from animal studies?

9:20     New imaging methods: How can they be applied in dystonia?


10:00   Coffee Break

             Late breaking news

10:30   TBA (chosen from posters submitted)

10:35   TBA (chosen from posters submitted)

10:40   TBA (chosen from posters submitted)

10:45   TBA (chosen from posters submitted)


Point and counter-point: Developmental or degenerative?

10:50   Dystonia is a developmental disorder

11:00   Dystonia is a degenerative disorder

11:10   Discussion

 

            Point and counter-point: Integrative models

11:20   Cervical dystonia is caused by a defect in the neural integrator for head control

11:30   Cervical dystonia is caused by a defect in the network for attentional orienting

11:40   Discussion


Chair’s summary & discussion with audience

11:50   Chair’s summary of the morning session

12:00   Open discussion of morning session


12:30   Lunch Break & Poster Session (provided for all delegates)

All posters viewable for entire meeting: 2nd third to present today from 13:30-14:30

IV. PHYSIOLOGICAL BASIS FOR DYSTONIA Chairs:


Functional changes in neural activity

14:30   Physiological changes in human dystonia: Where are we now?

14:50   Deep brain stimulation in humans: What can we learn about etiology?

15:10   Does dystonia begin in the basal ganglia?

15:30   Does dystonia begin in the cerebellum?


15:50   Coffee Break


Point and counter-point: All about sensorimotor integration

16:20   Abnormal sensory processes are a fundamental defect underlying dystonia

16:30   Abnormal sensory processes are a non-specific consequence of the disorder

16:40   Discussion


Point and counter-point: All about maladaptive plasticity

16:50   Abnormal plasticity is the fundamental defect underlying dystonia

17:00   Abnormal plasticity is a non-specific consequence of many movement disorders

17:10   Discussion

            Chair’s summary & discussion with audience

17:20   Chair’s summary

17:30   Open discussion of afternoon session

Day 3: Saturday, 6 June 2020

Day 3: Saturday, 6 June 2020

V. MOLECULAR MECHANISMS 

             Dystonia genes: A growing list

8:00     Overview of dystonia genetics

8:20     Dystonias with partial penetrance: What are the biological mechanisms?

8:40     Induced pluripotent stem cells: Novel technologies and application to dystonia

9:00     Shared biological pathways in dystonia: One or many paths to novel therapeutics?

9:20     Research resources: What is available?

 

10:00   Coffee Break

 

             Late breaking news

10:30   TBA (chosen from posters submitted)

10:35   TBA (chosen from posters submitted)

10:40   TBA (chosen from posters submitted)

10:45   TBA (chosen from posters submitted)

 

             Point and counterpoint: New gene nomenclature for dystonia

10:50   The value of the new gene nomenclature for dystonia

11:00   We do not need new names for old genes

11:10     Discussion

            Point and counterpoint: Rare monogenic dystonias vs common idiopathic dystonias

11:20   Results from monogenic dystonias provide novel insights for common idiopathic dystonia

11:30   Results from monogenic dystonias are not relevant to more common idiopathic dystonias

11:40   Discussion

 

            Chair’s summary & discussion with the audience

11:50   Chairs summary

12:00   Open discussion of morning session

 

12:30   Lunch Break & Poster Session (lunch provided for all delegates)

All posters viewable for entire meeting: 3rd third to present today from 13:00-14:00

VI. EXPERIMENTAL THERAPEUTICS

            Novel therapeutics on the horizon

14:30   Novel experimental oral therapeutics: What are the targets?

14:50   Botulinum toxin therapy: What are the new trends?

15:10   Surgical therapies: What’s next?

15:30   Clinical trials: What are the obstacles to testing new options?

 

15:50   Coffee Break

 

             Hot topics: Some recent successes

16:20   Physical and occupational therapy in dystonia:

16:40   Inherited dystonias with targeted therapies

17:00   PKAN: One enzyme defect, multiple targets

 

             Chair’s summary & audience discussion

17:20   Chairs summary of the session

17:30   Audience Discussion

 

18:00   CONFERENCE CONCLUDES